One of our past Projects
The Mapping and Characterization of Mutations Responsible for Canine Glaucoma
An investigation into the genetic causes of canine glaucoma was conducted at the University of Missouri-Columbia College of Veterinary Medicine. Initial objectives include verifying and updating the medical histories of members of the canine glaucoma families and obtain medical records and DNA from additional family members. Eventual goals of the investigation included mapping the glaucoma loci and identifying the mutations responsible for glaucoma in Bouvier des Flandres. Ultimately, the investigators hope to devise DNA tests for suspect glaucoma mutations and use these tests to determine if the test results consistently predict the disease phenotype. A similar study was done in Bassett Hounds. After the genes responsible for glaucoma are identified in Bouviers and Bassett Hounds, the researchers want to determine if the same genes are responsible for glaucoma in Dandie Dinmont Terriers and Welsh Terriers.
Owners of Bouvier des Flandres were encouraged to send blood samples if their dogs with glaucoma or their dogs with close relatives of glaucomatous dogs. Ideally siblings, parents or offspring of affected dogs, but blood from half-siblings, aunts, uncles etc. of affected dogs is also desired.
Dr. Paul Miller worked exclusively with the Bouvier Health Foundation to determine what is typical in the Bouvier eye and what peculiarities may preclude the onset of glaucoma. Dr Miller currently serves a Clinical Professor of Comparative Ophthalmology and Section Head of Ophthalmology at the School of Veterinary Medicine, University of Wisconsin-Madison. He is nationally recognized for his work in the diagnosis, treatment and prevention of glaucoma. He has given over 250 scientific and continuing education presentations, authored more than 65 scientific publications or book chapters, served as the editor for the ophthalmology section of the Five Minute Veterinary Consult and co-editor Doug Slatter’s Fundamentals of Veterinary Ophthalmology textbook, and has co-chaired the ACVO’s Basic Science Course for the Veterinary Ophthalmologist for the last 12 years. He is also president of the American College of Veterinary Ophthalmologists.