SNP Chips

SNP (Pronounced “snip”) Chips
What are they and why are they so important?

SNP stands for Single-Nucleotide Polymorphism

Polymorphism, the “P” in SNP, refers to locations within the DNA where the single nucleotide (the “SN” in SNP) varies from one individual to another. It is this variation of a single nucleotide that may signal the difference between disease-affected individuals and healthy individuals. Thus, identifying SNPs within the genome of individuals is critical in the hunt for DNA markers for genetic disease.

A DNA chip is a small piece of silicon glass to which a large number of synthetic single-stranded DNA oligonucleotides (“oligos”) have been chemically bonded. Oligos function as DNA probes: they “stick” (anneal) selectively only to those DNA molecules whose nucleotide sequences are exactly complementary. They can, therefore, be used to identify the presence of specific DNA sequences in a mixture of genes. In effect, oligos act like molecular “Velcro.” A computer “reads” the pattern of annealing and “reports” which alleles are present.

SNP chip technology is an extremely useful tool. It is used by researchers to locate DNA disease markers more quickly and thus makes many research projects more economically feasible. SNP chip technology will be vital to the BHF supported search for a genetic marker for glaucoma in the Bouvier breed.

Latest News

Canine Health Information Center

Canine Health Information Center
www.caninehealthinfo.org
Provides a source of health information for owners, breeders, and scientists that will assist in breeding healthy dogs. Bouviers were enrolled in CHIC in 2007
CHIC works with parent clubs to identify health screening protocols appropriate for individual breeds.
CHIC operates an informed consent database. All information regarding test results remains confidential unless the owner specifically authorizes release of the information into the public domain

Club National Specialty Schedule

American Bouvier des Flandres Club National Specialty. Check for updates on the Specialty Schedule for health testing details at: www.Bouvier.org

DNA Samples Collected for Research

An investigation into the genetic causes of canine glaucoma being conducted at the University of Missouri-Columbia College of Veterinary Medicine