Past project: The Mapping and Characterization of Mutations Responsible for Canine Glaucoma.
An investigation into the genetic causes of canine glaucoma was conducted at the University of Missouri-Columbia College of Veterinary Medicine. Initial objectives include verifying and updating the medical histories of members of the canine glaucoma families and obtain medical records and DNA from additional family members. Eventual goals of the investigation included mapping the glaucoma loci and identifying the mutations responsible for glaucoma in Bouvier des Flandres. Ultimately, the investigators hoped to devise DNA tests for suspected glaucoma mutations and use those tests to determine if the test results consistently predict the disease phenotype. A similar study was done in Bassett Hounds. After the genes responsible for glaucoma were identified in Bouviers and Bassett Hounds, the researchers wanted to determine if the same genes are responsible for glaucoma in Dandie Dinmont Terriers and Welsh Terriers.
Owners of Bouvier des Flandres were encouraged to send blood samples if their dogs have glaucoma or their dogs are close relatives of glaucomatous dogs. Ideally siblings, parents or offspring of affected dogs, but blood from half-siblings, aunts, uncles etc. of affected dogs was also accepted.
Our thanks go out to all the participants.