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Project: The Mapping and Characterization of Mutations Responsible for Canine Glaucoma.

An investigation into the genetic causes of canine glaucoma being conducted at the University of Missouri-Columbia College of Veterinary Medicine. Initial objectives include verifying and updating the medical histories of members of the canine glaucoma families and obtain medical records and DNA from additional family members. Eventual goals of the investigation include mapping the glaucoma loci and identifying the mutations responsible for glaucoma in Bouvier des Flandres. Ultimately, the investigators hope to devise DNA tests for suspect glaucoma mutations and use these tests to determine if the test results consistently predict the disease phenotype. A similar study is being done in Bassett Hounds. After the genes responsible for glaucoma are identified in Bouviers and Bassett Hounds, the researchers want to determine if the same genes are responsible for glaucoma in Dandie Dinmont Terriers and Welsh Terriers.

Owners of Bouvier des Flandres are encouraged to send blood samples if their dogs have glaucoma or their dogs are close relatives of glaucomatous dogs. Ideally siblings, parents or offspring of affected dogs, but blood from half-siblings, aunts, uncles etc. of affected dogs is also desired. Forms and instructions for sending samples can be found in the “Glaucoma and Lens Luxation” section of the University of Missouri-Columbia College of Veterinary Medicine Canine Genetic Diseases Network website (www.caninegeneticdiseases.net). For questions not answered on the website, you may contact the Project Coordinator Liz Hansen at HansenL@missouri.edu or by calling 573-884-3712.